“The best antidepressant would take your mental health grade from an F to F+, or C to C+.”
The actual claim here is more modest than the headline suggests. Case acknowledges that effect sizes shrink by half when studies get replicated rigorously. Also admits the observational data doesn’t prove causation. The real argument is just that supplements are cheap and safe, so why not try them. Fair enough. But “larger effect than antidepressants” is a low bar when you’re comparing to a C to C+ improvement.