“Patients on tiragolumab died faster than the control group.”
TIGIT was supposed to be the next Keytruda. Block the immune brake, free the immune system, cure the cancer. Roche, Merck, GSK, and Novartis lit billions on fire across nearly 49,000 patient enrollments and got nothing. Some of the drugs killed people faster than placebo. Beautiful theory, airtight biology, total failure. Not every brake is attached to wheels.