“If you have users in Sydney, Australia, any network request you make will need to travel 15,677km to make it there, as the crow flies.”
The real ping from Sydney to Virginia is about 215ms. A TLS 1.2 handshake on TCP takes three round-trips before a single byte of content moves. Chained requests in a badly built SPA stack that into thousands of milliseconds. Everyone outside the US pays that tax when a startup ships to one region.